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The remarkable story behind the revolutionary miracle cure for cancer, Gleevec. Novartis chairman Dr Dan Vasella describes its development and how he and Novartis orchestrated the break–neck approval and massive production of this amazing drug.
Pharmaceutical giant Novartis recently developed Gleevec, one of the first 'smart' drugs created to kill cancer cells without damaging healthy cells in the process. In early tests with a common form of leukemia and other types of cancer, Gleevec has been extraordinarily successful, and side effects have been astoundingly minimal. Gleevec communicates directly with cancer–causing chromosomes and interrupts the signal that causes excessive growth of certain white blood cells. Patients have seen their tumours shrink significantly, and some have disappeared altogether.
This is the inside story of the creation of this miracle drug, and how Novartis CEO and chairman Dan Vasella rallied the company to bring Gleevec to market in mass quantities and record time.
- Sales Rank: #469941 in Books
- Published on: 2003-06
- Released on: 2003-06-03
- Original language: English
- Number of items: 1
- Dimensions: 9.00" h x .93" w x 6.00" l,
- Binding: Hardcover
- 288 pages
From Publishers Weekly
Gleevec is one of the few cancer drugs hailed as a breakthrough that, so far, has largely lived up to its hype. Vasella, the CEO and chairman of pharmaceutical giant Novartis (which manufactures Gleevec), and Slater (Jack Welch & the GE Way) outline the development, remarkably successful clinical trials and accelerated production and approval process that led to the drug's speedy entry onto the market for the treatment of a rare cancer known as chronic myeloid leukemia (CML). Although the story's components-devoted scientists, risk-taking executives and activist patients-lend themselves to a gripping insider narrative, the book lacks the details and depth of feeling needed to make that story come alive. Repetition and stilted writing slow the account down further. As a result, the book reads largely as an extended press release for Novartis. Things begin to pick up toward the end, particularly when Vasella defends the high cost of the drug and discusses the challenge of managing patient, media and investor expectations. Gleevec may indeed represent a new direction for cancer research, but the excitement that fact should generate is not captured here.
Copyright 2003 Reed Business Information, Inc.
Review
“Compelling...Vasella reveals the innovative strategies that rushed this orange capsule to desperate patients in record time...a heroic saga.” (Fortune)
About the Author
Dr. Daniel Vasella has been the chairman and CEO of Novartis, one of the world's largest pharmaceutical companies, since it was formed in 1996. A native of Switzerland, he was a practicing physician before joining the industry as a pharmaceutical executive. He spent the first years of his business career in the United States before returning to Switzerland to take up his current position.
Most helpful customer reviews
5 of 6 people found the following review helpful.
Biased Book
By A. Reader
While this was a very interesting "inside view" of the pharmaceutical industry, the author (or ghost writer?) tries too hard to sound humanitarian, and ends up sounding rather fake (or as if he were going for a medical school interview). A lot of the book ends up being a justification of the marketing and sales of the drug, and ends up sounding heavy-handed. Also, the reader must be aware that this book does not tell the entire story of Gleevec - just search for it on the NY Times, and the patients will tell you the darker side of the tale. In the end, this book is just another marketing scheme for this niche drug, and should be treated as such.
5 of 5 people found the following review helpful.
Did someone proofread this before publishing?
By The Microbe
What appeared to be a good story on an amazing cancer drug discovery turns out to be a disappointment in reading experience.
There is no doubt that the author is intelligent; (given that he did find this amazing drug and remains to be a CEO of a huge pharmaceutical company) but someone should have helped him out with his writing.
There were run on sentences, misspelled words and the flow of his writing doesn't get the reader excited. Instead, it conveys a sense of sensationalism and unnecessary drama.
7 of 11 people found the following review helpful.
Gleevec Book
By Paleosapient
As someone who has CML, the disease that Gleevec was developed for, and as someone for whom Gleevec has been a life-saver, I can attest to the the fact that this book is a valuable and interesting read.
This book makes note of the important part the internet played in the rapid FDA approval of this "proof of concept" drug. It also tells the personal story of how several persons that have used this drug lives' have been affected. Some parts of this book may bring tears to your eyes.
It is becoming apparent that Gleevec will be of help against several other diseases, besides just CML.
As a "proof of concept" drug, Gleevec is truly unique, promising and exciting, and that fact alone makes the telling of its story so worthwhile.
I am totally satisfied with this book, and am glad that I bought it.
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